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The proposed mechanism for the erythropoietic effects of SGLT2 inhibitors revolves around the idea that the heightened workload on renal tubule, caused by increased sodium delivery to the distal part after SGLT2 inhibition could induce renal medullary hypoxia [91]

Breathomics studies further identified increased exhaled proline, 4-hydroxyproline, and branched-chain amino acids (BCAAs: valine, leucine/isoleucine, alanine) in IPF patients [133]

HDL-induced NO underlies many of HDLs beneficial properties to endothelial cells, including HDL-induced vasodilation, tightening of cell-to-cell junctions and increased barrier function, differentiation of endothelial progenitor cells, cell survival and proliferation, cell migration, inhibition of apoptosis, and suppression of adhesion molecule expression

Pharmaceutics 589 , 119776 (2020)

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