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Pioneering studies by Katz, Miledi, and Douglas first established intracellular Ca 2+ concentrations as a general coupling factor between membrane depolarization and vesicular exocytosis

So, why is this combination getting so much attention

doi: 10.1038/s41598-018-27231-5 322 OllivierN.DesmetR.DrobecqH.BlanpainA.BollE.LeclercqB.et al

While it does not enhance performance in healthy tissue , it ensures injured tissue regains pre-injury functionality, potentially reducing re-injury risk