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Under resting conditions, MOTS-c is mainly distributed in the mitochondria outside the nucleus (5, 7, 19)

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In preclinical and in vitro research, 5-Amino-1MQ is used to investigate NNMT enzyme biology, NAD+ metabolism and the salvage pathway, sirtuin activation, energy expenditure and thermogenesis, adipose-tissue biology and body composition, insulin sensitivity, and methylation/epigenetic regulation

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