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In the infected fly gut, ROS was produced from the NADPH oxidase (DUOX) protein of epithelial cells, which is triggered by invading bacteria [32]

Volatiles were then evaporated under reduced pressure and the crude residue was dry-loaded and purified by chromatography on silica gel (DCM/MeOH gradient from 99:1 to 85:15) to afford 809 mg (83%) of title compound as a white solid

Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress

Adana Alparslan Trke Science and Technology University, Scientific Research and Publication Ethics Committee for Science and Engineering Sciences reviewed and approved this study with the approval number E-76907350-050.01.04-84322, dated 30/01/2024

However, P53 was also reported to repress ferroptosis by combining with dipeptidyl peptidase-4, which could interact with NOX1 on cellular membrane and lead to lipid peroxidation without P53 (98)

Identification and characterization of a novel snat2 (slc38a2) inhibitor reveals synergy with glucose transport inhibition in cancer cells