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[8] Approved-drug labeling as a reference point The FDA-approved label for mecasermin (native IGF-1) provides the closest regulated analog and lists recognized risks of IGF-1 exposure, including hypoglycemia (owing to IGF-1s insulin-like metabolic action), intracranial hypertension, tonsillar/adenoidal hypertrophy, and the requirement for caution regarding neoplasia

Behav Brain Res 414:113486 Yang L, Zheng L, Wan Y, Chen Z, Li P, Wang Y (2018) Metoprolol, N-acetylcysteine, and Escitalopram prevents chronic unpredictable mild stress-induced depression by Inhibition of Endoplasmic reticulum stress

115,116 Clinical application of metabolic analysis in EBV-related cancers Serum metabolic profiling and radiotherapy in NPC Based on gas chromatography-mass spectrometry (GC-MS) metabolomics coupled with partial least squares-discriminant analysis, an NPC discrimination model was established with a sensitivity of 88% and a specificity of 92%