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SharmaASharmaRZhangZLiawKKambhampatiSPPorterfieldJEet al

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The inherent heterogeneity of botanical raw materials (due to seasonal or geographical variations) leads to significant challenges in Chemistry, Manufacturing, and Controls (CMC), particularly regarding batch-to-batch inconsistency in nanoparticle size, charge, and drug loading, which complicates quality control and reproducibility [153, 154]