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Mutations are introduced into genes encoding key enzymes in C1 metabolism, most notably cystathionine beta-synthase (CBS), which converts homocysteine to cystathionine in a vitamin B6-dependent manner [2, 131]

doi: 10.14218/JCTH.2024.00135 5 BauschDPauschTKraussT

Nat Commun 13(1):3676 Mbah NE, Lyssiotis CA (2022) Metabolic regulation of ferroptosis in the tumor microenvironment

b , Models were tested in four independent cohorts (Covance, LonGenity, Stanford-ADRC, SAMS)

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These include how bad the B12 deficiency is, any health issues, and how well the body responds to the treatment