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To validate these findings, future work should focus on randomized controlled trials testing integrated lifestyle interventions using functional foods and exercise, with endpoints such as recurrence, inflammation, and quality of life and personalized, omics-guided strategies to match specific dietary and physical activity regimens to individual epigenetic or metabolic profiles

These observations are usually mild and manageable in research settings but they highlight the importance of monitoring and adjusting research protocols as needed

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For instance, curcumin has been found to stimulate the expression of glutamate-cysteine ligase , the enzyme responsible for initiating glutathione synthesis