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Cluster 1 contains six genes ( CCND1, CDKN1B, MDM2, CDKN2B, CDKN1A ), is identified as mixed for glutathione metabolism and detoxification of ROS, and scored the lowest FDR of 6.3 10

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Recommendation Genetic testing for HFE p.Cys282Tyr and p.His63Asp should be offered to all individuals particularly those of European descent having both raised serum ferritin and transferrin saturation, individuals with an isolated elevated serum ferritin or transferrin saturation where there is no other cause identified, and first-degree relatives of individuals with HFE-related hemochromatosis (HIGH QUALITY of EVIDENCE

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