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In addition, current studies indicate that a low-potassium diet, low LPS levels, and uremic toxins also increase intestinal permeability, which leads to bacterial translocation [103, 114]

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Describing herself as largely 'the lab rat' when she joined the diabetes team, Knudsen remembers she spent 'the first year in a cold room with three technicians to screen hundreds of thousands of compounds to see if they could wedge into the GLP-1 receptor and other targets of interest just snugly enough to stimulate insulin secretion.' To help speed up the screening process, Knudsen devised a method to test 96 candidates in one go instead of just one

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