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At the same time, compared to HCs, the levels of a wide range of metabolites such as glutamine, asparagine, N-Formimino-glutamate, putrescine, serotonin, kynurenine, 2-Aminomuconate, Cys-Gly, 5-Aminolevulinate, and pyridoxine were reduced in the plasma of R group ( Figure 5C , Supplementary Figure 4A )

Autophagy is a highly conserved cellular process that involves the formation of autophagosomal vesicles

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doi: 10.1016/0022-4731(88)90156-2 242 TsurufujiSSugioKTakemasaF

Laboratory Monitoring: Assessing Hepatic and Renal Function Blood will be drawn for baseline levels of alanine aminotransferase (ALT) , aspartate aminotransferase (AST) , bilirubin, blood sugar, serum urea nitrogen (BUN) , serum creatinine, electrolytes and prothrombin time to monitor hepatic and renal function and electrolyte-fluid balance