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First, by acting as a NO donor or reservoir, GSNO may facilitate S-nitrosylation of mitochondrial proteins, thereby preserving mitochondrial function and suppressing ROS generation

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The WW and SH3 domains might be positioned on one side of the FFO, because there are huge spaces between the domains for the linker region between the F-BAR and the WW domain to pass through, as shown hypothetically in Fig

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