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Casgevy and Lyfgenia: two gene therapies for sickle cell disease

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Research has indicated that deficiencies in ACSL4, a lipid metabolism enzyme associated with ferroptosis, can lead to increased Mixed Lineage Kinase Domain-like Protein (MLKL), a protein involved in necrosis execution, making cells more susceptible to ferroptosis

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Numerous in vitro studies have substantiated the generation of hydroxyl radicals ( OH), which can be elucidated through the following reactions (Valko et al., 2005[430]): The overall reaction of steps (2) and (3) is termed the HaberWeiss reaction: Furthermore, subsequent reactions may also occur The decomposition of H 2 O 2 in the presence of Fe(II), known as the Fenton reaction (3), produces OH, which can react with various biomolecules, including lipids, proteins, and DNA, at diffusion-limited rates (Lloyd et al., 1997[279])