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These microneedles, composed of trimethylolpropane triacrylate, polyacrylic acid, and photopolymerizable derivatives of polyethylene glycol and polycaprolactone, were capable of puncturing mouse skin and releasing the fluorescent drug rhodamine

In one subject on daily furosemide therapy, the dose was increased after wk 2 of the dosing period and the previously borderline renal insufficiency worsened slightly (creatinine rose from 119 mol/L to 159 mol/L)

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