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Cell 152 , 909922 (2013)

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An overproduction of ROS can overwhelm the cellular antioxidant defenses, thereby causing oxidative stress [67]

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In both behavioural despair paradigms, the antidepressant effects of SERT increased significantly with SILY at a concentration of 280 mg/kg of feed, although it decreased at 140 mg/kg of feed, suggesting that high concentrations of SILY could elicit an additive beneficial effect