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Retatrutide is an investigational triple receptor agonist that targets the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors simultaneously

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Zhou Y, Li L, Li S, Li S, Zhao M, Zhou Q et al (2019) Autoregenerative redox nanoparticles as an antioxidant and glycation inhibitor for palliation of diabetic cataracts

J Clin Oncol 41(20):35953607 Patil VM, Noronha V, Menon N, Singh A, Ghosh-Laskar S, Budrukkar A et al (2023) Results of phase III randomized trial for use of docetaxel as a radiosensitizer in patients with head and neck Cancer, unsuitable for Cisplatin-Based chemoradiation

Conversely, in the high gene score group, Gemcitabine, PD0325901 (a MEK inhibitor), Ulixertinib (an ERK inhibitor), and Palbociclib (a CDK4/6 inhibitor) displayed greater sensitivity, indicating a potentially better therapeutic response to these agents ( Figure 10G )