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For example, gemcitabine thermosensitive hydrogels or microspheres are used for intraperitoneal perfusion to treat peritoneal metastasis, which can form a drug sustained release reservoir in the peritoneal cavity, prolong local exposure time and reduce systemic toxicity (Xu et al., 2016)

J Neurosci 26(10):28142819 Jin S, Wu J, Wang C, He Y, Tang Y, Huang L, Zhou H, Liu D, Wu Z, Feng Y, Chen H, He X, Yang G, Peng C, Qiu J, Li T, Yin Y, He L (2025) Aspartate metabolism-driven gut microbiota dynamics and rip-dependent mitochondrial function counteract oxidative stress

Due to the increased viscosity of the thrombus, it is more difficult for blood to pass through the blood vessels, which may result in slower blood flow

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Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: implications for oxidative stress and insolubility of newly synthesized proteins