glutathione conjugation target Glutathione-Mediated of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation The role of glutathione-S-transferase in

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First, since HSL is apparently the primary diacylglycerol lipase in adipose tissue, the accumulation of diacylglycerol in WAT of HSL null mice might interfere with normal adipocyte differentiation or function through the activation of protein kinase C family members and their downstream targets, which are known to affect cell proliferation, apoptosis, and differentiation (Figure 2A)

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