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Cell 157 , 1262 (2014)

However, its mechanisms remain incompletely elucidated and face multifaceted challenges

Abbreviations IVP: In Vitro Embryo Production IVM: In Vitro Maturation GV: Germinal Vesicle GVBD: Germinal Vesicle Breakdown MII: Metaphase II MPF: Maturation-Promoting Factor CDK1: Cyclin-Dependent Kinase 1 cAMP: Cyclic Adenosine Monophosphate cGMP: Cyclic Guanosine Monophosphate PDE3A: Phosphodiesterase 3A PKA: Protein Kinase A LH: Luteinizing Hormone FSH: Follicle-Stimulating Hormone EGFR: Epidermal Growth Factor Receptor MAPK: Mitogen-Activated Protein Kinase PI3K/Akt: Phosphoinositide 3-Kinase / Protein Kinase B ROS: Reactive Oxygen Species GSH: Glutathione OCM: One-Carbon Metabolism SAM: S-Adenosylmethionine SAH: S-Adenosylhomocysteine COCs: CumulusOocyte Complexes TZPs: Transzonal Projections EVs: Extracellular Vesicles SPOM: Simulated Physiological Oocyte Maturation IBMX: 3-Isobutyl-1-Methylxanthine TUDCA: Tauroursodeoxycholic Acid ALA: Alpha-Lipoic Acid CoQ10: Coenzyme Q10 EGF: Epidermal Growth Factor IGF-1: Insulin-Like Growth Factor 1 BMP: Bone Morphogenetic Protein GDF9: Growth Differentiation Factor 9 BMP15: Bone Morphogenetic Protein 15 FGF: Fibroblast Growth Factor PUFAs: Polyunsaturated Fatty Acids BSA: Bovine Serum Albumin HA: Hyaluronic Acid HAS2: Hyaluronan Synthase 2 PTGS2: Prostaglandin-Endoperoxide Synthase 2 TNFAIP6: Tumor Necrosis Factor Alpha-Induced Protein 6 BCL2/BAX: Anti- and Pro-Apoptotic Proteins MDA: Malondialdehyde BCB: Brilliant Cresyl Blue ATP: Adenosine Triphosphate References Abdala A, Elkhatib I, Bayram A, Arnanz A, El-Damen A, Melado L, Lawrenz B, Garrido N, Fatemi HM, de Munck N (2021) Different CO(2) settings (6.0% vs 7.0%) do have an impact on extracellular pH of culture medium (pHe) and euploidy rates rather than on blastocyst development: a sibling oocyte study

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