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In addition, it is known that the absence of BDNF-TrkB signalling in central neurons can alter metabolism

Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants

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NAD+ operates across several distinct and complementary cellular mechanisms, making it unique among research compounds in its breadth of biological relevance: Redox Metabolism: NAD+ acts as a hydride-accepting electron carrier in central metabolic pathways glycolysis, the Krebs cycle, beta-oxidation of fatty acids, and the mitochondrial electron transport chain