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The biosynthesis of glutathione is catalyzed by two ATP-dependent enzymes in two steps

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D ) Distribution of doxorubicin (blue) in relation to blood vessels (red) in normal mouse liver

The structure of the ZZ1-SO 2 H-induced ternary complex was obtained by first docking the previous coordinates of the YPEL5WDR26 module (PDB 8QBN) 44 and BRD4 BD1 (PDB 3MXF) 34 in UCSF Chimera (version 1.11.2) 88 into the postprocessed map and manually refining the differing parts (for example, removing the parts of the BRD4 BD facing away from the YPEL5 interface, which are less ordered and, thus, blurry or invisible in the high-resolution reconstruction)

Journal of Clinical Pathology 2013, 66 (12), 1033-1045