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Kings College Hospital (KCH), London has the largest cohort of transplanted and non-transplanted adult and paediatric WD patients in the UK

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The active-site cavity, which is located between the two domains, comprises a glutathione binding site (G-site), formed mainly by the N-terminal domain, and a hydrophobic substrate-binding site (H-site), which is formed by the C-terminal domain

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Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity