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The effects of the intervention on the outcome variables for each group were assessed using the nonparametric tests (Friedman test and Wilcoxon test)

Caspases, which are cysteine-dependent aspartate-directed proteases regulated by Bcl-2 family proteins, heat shock proteins, and apoptosis inhibitors, become active in the cytosol upon activation and then cleave a wide range of proteins, are common features of the diverse routes leading to apoptosis ( Fig

Regular physical exercise is critical for managing comorbidities and lowering systemic inflammation, which has been associated to increased TMAO production [103109]