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oxymetazoline topical (Rhofade) niacinamide topical The drug brimonidine topical (Mirvaso) can also be used but it is known for sometimes leading to rebound redness that can be worse than original symptoms

10.1073/pnas.2001393117 [DOI] [PMC free article] [PubMed] [Google Scholar] Haynes WMLDRBTJ (2016)

In the same study, elevated expression of inflammatory genes was also linked with decreased thickness of the subgenual ACC, hippocampus, and caudate in the mood-disordered group (213)