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The pathogenic role of the renal proximal tubular cell in diabetic nephropathy

Type I collagen is the most abundant collagen in the body and provides tensile strength to tissues including skin, tendons, ligaments, and bone

although many of these publications center on animal studies, there are an increasing number of human clinical trials

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these include ALT (alanine aminotransferase, a marker of liver cell damage), bilirubin (an indicator of liver excretion function), and albumin levels & prothrombin time (indicators of liver synthesis function) (Liaw 2009)