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10.1016/j.envres.2023.115497 105 MagtanongL.KoP

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It can also be depleted by chronic stress, alcohol, smoking, digestive issues, cardiovascular disease, illness, and aging because stomach acid production decreases with age, reducing B12 absorption significantly

Additionally, SAM plays a pivotal role as the primary provider of methyl groups, which are crucial for various processes, including gene regulation

Inhibition of phospholipase D 1/2 (PLD1/2) blocks ROS accumulation, iron metabolic disorders, and NLRP3 activation simultaneously, indicating that both processes share upstream regulatory nodes controlled by the PLD signaling pathway