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Depending on cellular state and stress cues, TP53 can promote ferroptosis by repressing SLC7A11 to limit cystine uptake and GSH synthesis, inducing spermidine/spermine N1-acetyltransferase 1 ( SAT1 ) to enhance ROS generation through polyamine catabolism, and upregulating glutaminase 2 ( GLS2 ) to increase -ketoglutarate production and mitochondrial ROS 154-156

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110 For example, GFAP levels as well as densities of GFAP-positive astrocytic profiles are decreased in a single prolonged stress model of PTSD

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Artesunate is a clinically well-tolerated compound that acts synergistically with sorafenib to induce ferroptosis in the HCC cell lines Huh7, SNU-449, and SNU-182 (97)

Lactulose to mannitol ratio in humans The ratio of urinary excretion of lactulose to mannitol (LA/MA) was used to measure the intestinal mucosal permeability in ten RA patients and ten healthy controls who underwent colonoscopy, with higher ratios indicative of increased intestinal permeability as previously described 33