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200,201 Under ROS stress, thioredoxin-interacting protein (TXNIP) dissociates from TRX and activates NLR family pyrin domain containing 3 (NLRP3) inflammasomes, leading to caspase-1 activation and GSDMD cleavage, forming membrane pores and releasing proinflammatory cytokines

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For example, sugar units like mannose and galactose form multivalent hydrogen-bonding networks with lectins (e.g., macrophage surface CD206 or bacterial surface LecA) through hydroxyl groups and cyclic structures, enabling specific molecular recognition and targeted interactions (Teng et al., 2024

Tramadol exerts antioxidant effects by reducing lipid peroxidation levels and enhancing antioxidant enzyme activity and displays potential therapeutic benefits in treating LL-IRI (Takhtfooladi et al., 2014)

doi: 10.1111/dth.12464 363 MehtaLRDworkinRHSchwidSR

Target-selective protein S-nitrosylation by sequence motif recognition