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In parallel with MTXs most well-known targets, several NAD+-dependent enzymes were inhibited by the antifolate in vitro : 2-oxoglutarate, isocitrate, malate, pyruvate, succinate, 6-phosphogluconate and glucose-6-phosphate dehydrogenases, glutamate-cysteine ligase, glutathione reductase, and glutathione peroxidase (29)

10.1038/s41598-025-86823-0 11 HuangM.YuQ.ZhuY.ZhangJ.HeY.ZhuY.et al (2025)

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In addition, slow-growing poultry had a higher percentage of oxidized fibers in the leg meat than in the breast meat 58

Furthermore, a study in 2020 revealed that S