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Not only is it safe, but it is highly recommended

& Izumo, S

Yu H, Kim PM, Sprecher E, Trifonov V, Gerstein M

The established urinary threshold level of 150 g/mL may be reached (rarely, but possibly) in some individuals within 6-20 hours of taking some long-acting therapeutic formulations

[PubMed: 10744772] 623

found that monocyte-derived macrophages from patients with CD were less susceptible to cell death induced by phorbol-12-myristate-13-acetate and speculated that this could result in the prolonged presence of pro-inflammatory macrophages in the gut and incomplete resolution of inflammation [9]