Neurogenetics 5 , 135140 (2004)
Once daily fecal output stabilized (approximately one week later), mice were injected intraperitoneally (i.p.) with different doses of morphine (3 mg/kg, 6 mg/kg, and 10 mg/kg)
The busulfanglutathione adduct undergoes a nonenzymatic -elimination reaction yielding THT at pH 8.0 (Roberts and Warwick, 1961)
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Mitochondrial Targeting & Cardiolipin: Mitochondria-Targeted Peptides Protect against 1-Methyl-4-phenylpyridinium Toxicity (Journal of Biological Chemistry) Cardiovascular Protection: The mitochondria-targeted peptide SS-31 prevents mitochondrial dysfunction (British Journal of Pharmacology) Renal Health & Oxidative Stress: Mitochondria-targeted peptide SS-31 attenuates renal injury (Journal of the American Society of Nephrology) Neuroprotection in Aging: SS-31 Ameliorates Mitochondrial Dysfunction and Cognitive Deficits (Frontiers in Aging Neuroscience) Mechanism of Action (Bioenergetics): Cell-permeable peptides as mitochondrial antioxidants (AAPS Journal) Product Name: SS-31 (Elamipretide/Bendavia) Molecular Formula: CHNO Molecular Weight: 656.82 g/mol Amino Acid Sequence: D-Arg-Dmt-Lys-Phe-NH (Dmt = 2,6-dimethyltyrosine) Form: Lyophilized (freeze-dried) powder Purity: 98% (HPLC verified) Appearance: White to off-white powder Quantity per Vial: 10 mg