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Crit Rev Biochem Mol Biol 57:333350 Huang D, Kraus WL (2022) The expanding universe of PARP1-mediated molecular and therapeutic mechanisms

Elevated homocysteine has been linked with brain atrophy, cognitive decline, and an increased risk of dementia, making it one of the most widely studied biomarkers of brain health

Although reactive electrophiles such as chloroacetamides are generally considered to be promiscuous in target binding, we demonstrated here using a BODIPY-labelled analogue that the chloroacetamide-based GSTO1 inhibitor C1-27 exhibited a low degree of nonspecific reactivity

Given that M-cells have well-accepted BT capability and overlie intestinal lymphoid aggregates, M-cell mediated BT is one plausible mechanistic explanation [16, 17]

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Given that elevated CRP is a putative predictor of PTSD development (Eraly et al., 2014) reductions observed may reflect therapeutic potential