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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

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Tirzepatide may be appropriate if: You have tried semaglutide with good tolerance but want to see if tirzepatide would enhance your weight loss results, you have type 2 diabetes but have not had adequate glucose control on other GLP-1 medications, or have sleep apnea

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