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Naive CD4 + T cells were polarized into non-pathogenic (np) T H 17 cells in the presence of recombinant human (rh) TGF-1 (0.4 ng/mL), recombinant murine (rm) IL-6 (20 ng/mL), rhIL-23 (20 ng/mL), and antibodies to IFN- (polyclonal, 10 g/mL) and IL-4 (polyclonal, 10 g/mL)