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The patient was advised to review every 3 weeks and similar sessions were carried out up to 12 weeks, accounting for a total of 5 sessions (at baseline, week 3, week 6, week 9, and week 12) with a final follow-up at week 16

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6.2 Hypoxia In the normal adult intervertebral disc (IVD), oxygen partial pressure gradually decreases from about 10% in the outer annulus fibrosus to less than 1% in the central region, placing the entire disc in a state of continuous hypoxia, which may further decrease during degeneration (Urban, 2002)