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At present, this includes Apolipoprotein E4 (APOE4) , a well-established gene polymorphism that increases risk for Alzheimers Disease (AD) and has been associated with cognitive impairments (Reitz and Mayeux, 2010

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Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML, Allayee H, Lusis AJ, Hazen SL

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7 Summary and discussion In recent years, studies have provided new insights into the development of RA