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The increase in the reduced form of glutathione caused a decrease in the amount of GSSG and inversely (Fig

Limitations of the study MBOAT1 knockdown or gene-disruption is not sufficient to sensitize to GPX4 inhibition alone, and this may be explained by redundancy with MBOAT2

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In addition, 6-C-(E-phenylethenyl)naringenin inhibited HCC tumor growth and lung metastasis in a mouse model of Huh7 cells without apparent systemic toxicity and increased the sensitivity of HCC cells to 5-fluorouracil, cisplatin, and sorafenib [58]

This shift suggests that the alcoholic group is involved in coordination, supporting the role of vit-OH as a monodentate ligand