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P62/SQSTM1, the most studied autophagy receptor, binds to autophagic membranes through its LIR or GIM structural domains, to the proteasome through its Phox and Bem1p structural domains (PB1), and to ubiquitinated substrates through its Ub-associated structural domain (UBA)

Skin Aging Of all the organs, the skin is the most conspicuous to display signs of aging or dermal changes, which are due to chronological (intrinsic) and photoaging (extrinsic) mechanisms [2, 10, 14]

[DOI] [PubMed] [Google Scholar] 24.Mereto G.C., Balestra L., Henriquet F

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AMPK stacking caution: MOTS-c activates AMPK