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However, another study showed that 25 g/ml of ciprofloxacin can cause cells to lose 60% mtDNA content, which therefore results in a decreased mitochondrial membrane potential and mitochondria-mediated calcium buffering capacity

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J Surg Res (2006) 131(1):2640

This asymmetry can be explained by the localization of phosphatidylcholine (PC) and sphingomyelin (SM) to the outer leaflet, while phosphatidylethanolamine (PE) and phosphatidylserine (PS) are mostly confined to the inner leaflet