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The liver is especially relevant because it produces and uses large amounts of SAM, manages homocysteine through both remethylation and transsulfuration, synthesizes glutathione and carries out methylation- dependent reactions

Therefore, the CrAT mechanism, which ensures a shift towards the production of acetylcarnitine, is considered beneficial

This is accompanied by the upregulation of ER stress-related proteins, including PERK, IRE1, ATF4, CHOP, XBP-1 and ATF6

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Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment