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Description

Additionally, they downregulated Matrix Metalloproteinases (MMP2 and MMP9), key mediators of uterine matrix degradation, and suppressed p-STAT3 signaling while enhancing p-IRS1 and p-PI3K expression, indicating improved insulin signaling in the uterine tissues

doi: 10.1038/s41586-023-05915-x

Importantly, recent clinical trials using such personalized interventions demonstrated improved glycemic control and reduced HbA1c in both prediabetic and newly diagnosed T2D when compared to a Mediterranean diet intervention [120, 121]