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As proof of concept that endosomal maturation inhibitors have clinical potential, CQ and hydroxy-CQ (HCQ), lysosomotropic agents that block endosomal acidification, are used to treat SLE 49 , RA 50 and, to a lesser extent, sJIA 51

Recently, it has been believed that the depletion of NAD+ with aging is associated with oxidative stress injury, which is a crucial factor of aging, and NAD+ deficiency has a certain degree of duality for myocardial protection

IGF-1 forms the central core elements of astrocyte functions, such as the regulation of glucose uptake, glutamate transport, and protection against oxidative stress in the brain [44, 131, 132]

10.3389/fimmu.2023.1051606 111 XiaY.YangR.WangH.HouY.LiY.ZhuJ.et al (2022a)

Further prospective studies are essential to develop non-invasive biomarkers for screening FALD

Many strategies have been established to induce ferroptosis in cancer cells [9,10,11]