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One study has shown that supplementation with aspartate, glutamate, and glutamine under normal or low energy status can maintain the energy homeostasis of small intestinal mucosa in piglets by either replenishing the Krebs cycle or downregulating AMP activated protein kinase (Wang et al., 2022a)

Interestingly, in our sibling cohort we also observe that children with the most severe form of konzo (stage 3), have on average the lowest GPx3 levels as well as the largest difference when compared to unaffected siblings

The depletion in GSH in dopaminergic SN neurons leads to decreased E1 activity and subsequent UPP disturbance [67]

Despite the common morphological hallmarks and shared triggers, it has become clear that the signaling pathways might differ

Mellman, I., Chen, D

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