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Plasma l-carnitine levels in subjects undergoing cardiac evaluation ( n = 2,595) predicted increased risks for both prevalent cardiovascular disease (CVD) and incident major adverse cardiac events (myocardial infarction, stroke or death), but only among subjects with concurrently high TMAO levels

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Figure 1 L-carnitine, a TMA found abundantly in red meat, has aroused considerable research interest because an increasing number of studies have found that it is associated with atherosclerosis ( via intestinal flora-derived CntA/CntB , and also into -butyrobetaine and betaine, and further converted to TMA through the yeaW/yeaX enzyme system of intestinal flora (Figure 1