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Long-term metformin treatment is associated with reduced serum B12 in a dose- and duration-dependent manner

The how peptides work article provides the biological context for understanding these interactions

10.1016/j.cell.2006.07.035 Cell

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It makes sense then that if you have low B12 to the point of a deficiency, it can cause a myriad of physical and mental symptoms that can zap your energy and make you feel like you have one foot in the grave