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Finally, we previously used an animal experiment to show that RGC loss in Nrf2 knockout mice was much faster after optic nerve damage was induced by crushing the nerve 41

Overall, ferroptosis plays a crucial role in HD pathogenesis, and targeting ferroptosis represents a promising therapeutic strategy for HD (Figure 4F)

In recent years, increasing evidence has suggested that traditional Chinese medicine and its active monomers can inhibit hepatocyte ferroptosis, exerting a protective effect against alcohol-induced liver injury

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