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ART can inhibit the phosphorylation and nuclear translocation of STAT3 [27], thereby disrupting the positive feedback loop between STAT3 and IL-6/JAK2 in various tumor models, including colon and liver cancers [28, 29]

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[DOI] [PubMed] [Google Scholar] 14.El Zein R, Ispas-Szabo P, Jafari M, Siaj M, Mateescu MA

Dose escalation is not always better starting low (300 mcg) and adjusting as needed is recommended

Takagi D, Miyagi A, Tazoe Y et al (2020) Phosphorus toxicity disrupts Rubisco activation and reactive oxygen species defence systems by phytic acid accumulation in leaves

Among the drugs predicted to target GSTM1, curcumin appears to be the most promising