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The reducing environment promotes the DNA binding of HIF-1 in the nucleus, which is achieved by TXN-mediated Ref-1 reduction [28, 29]

1) Decipher cell type-specific ferroptosis regulatory networks: Use integrated single-cell multi-omics (scRNA-seq, Single-cell Assay for Transposase-Accessible Chromatin with High-throughput Sequencing (scATAC-seq), and single-cell metabolomics) to map ferroptosis-related gene expression, chromatin accessibility, and metabolite profiles across renal cell types in health and disease

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10.1016/j.redox.2015.03.003 Redox Biol