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The benefits also extended to major outcomes such as regression of left ventricular hypertrophy, improvement in New York Heart Association class and cardiac function, fewer hospitalizations and even reduction of cardiovascular mortality rates

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However, some studies have proven that -arrestin 2 mediates acute rather than chronic opioid tolerance, which indicates that opioid-induced antinociceptive tolerance may even occur without the activation of -arrestin 2 [96], as it should be