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It is now well established that CFTR functions as a cyclic adenosine monophosphate (cAMP)-dependent Cl channel in the apical membrane of secretory epithelia

In patients with osteosarcoma, which is the most common bone tumor, serum, and urinary metabolomics revealed a distinct phenotype compared to healthy patients, suggesting that downregulation of central carbon metabolism and increased glutathione metabolism were characteristic features of osteosarcoma 14

Additionally, when vitamin C is incubated with peripheral blood lymphocytes in vitro, it reduces the production of various inflammatory cytokines, such as TNF- and IFN-, induced by lipopolysaccharide, whilst increasing the production of the anti-inflammatory cytokine IL-10 (50)

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They mediate inflammatory responses

This excessive ROS accumulation leads to oxidative stress, which disrupts metabolic pathways, ultimately contributing to wrinkles and other symptoms of aging (Mai et al., 2019)